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Article

Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy.

Molecular neurodegeneration - 3 May 2022

Brody A Harrison, Nies Sarah Helena, Guan Fulin, Smith Levi M, Mukherjee Bandhan, Salazar Santiago A, Lee Suho, Lam Tu Kiet T, Strittmatter Stephen M

Abstract excerpt

BACKGROUND: Genetic variation at the PTK2B locus encoding the protein Pyk2 influences Alzheimer's disease risk. Neurons express Pyk2 and the protein is required for Amyloid-β (Aβ) peptide driven deficits of synaptic function and memory in mouse models, but Pyk2 deletion has minimal effect on neuro-inflammation. Previous in vitro data suggested that Pyk2 activity might enhance GSK3β-dependent Tau phosphorylation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35501917
DOI: 10.1186/s13024-022-00526-y
PMCID: PMC9063299

Genes

PTK2B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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