Article
Casein kinase 2 phosphorylation of protein kinase C and casein kinase 2 substrate in neurons (PACSIN) 1 protein regulates neuronal spine formation.
The Journal of biological chemistry - 29 Mar 2013
Schael Sylvia, Nüchel Julian, Müller Stefan, Petermann Philipp, Kormann Jan, Pérez-Otaño Isabel, Martínez Sonia Marco, Paulsson Mats, Plomann Markus
Abstract excerpt
The PACSIN (protein kinase C and casein kinase 2 substrate in neurons) adapter proteins couple components of the clathrin-mediated endocytosis machinery with regulators of actin polymerization and thereby regulate the surface expression of specific receptors. The brain-specific PACSIN 1 is enriched at synapses and has been proposed to affect neuromorphogenesis and the formation and maturation of dendritic spines....
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