Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the Tyrosine Kinase Fyn.

Abstract excerpt

The protein tyrosine kinase Pyk2 is encoded by PTK2B, a novel Alzheimer's disease (AD) susceptibility variant, with the PTK2B risk allele being associated with increased mRNA levels, suggestive of increased Pyk2 levels. However, the role of Pyk2, a member of the focal adhesion kinase (FAK) family, in AD pathology and its regulation are largely unknown. To address this, we generated mice with neuronal expression...

Topics

• Adenosine Triphosphate
• Animals
• Disease Models, Animal
• Disks Large Homolog 4 Protein
• Focal Adhesion Kinase 2
• Gene Expression Regulation
• HEK293 Cells
• Hippocampus
• Humans
• Mice
• Mice, Inbred C57BL
• Mice, Transgenic
• Microtubule-Associated Proteins
• Mutation
• Phosphorylation
• Proto-Oncogene Proteins c-fyn
• RNA, Messenger
• Tauopathies