Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the Tyrosine Kinase Fyn.

Journal of Alzheimer's disease : JAD - 1 Jan 2018

Li Chuanzhou, Götz Jürgen

Abstract excerpt

The protein tyrosine kinase Pyk2 is encoded by PTK2B, a novel Alzheimer's disease (AD) susceptibility variant, with the PTK2B risk allele being associated with increased mRNA levels, suggestive of increased Pyk2 levels. However, the role of Pyk2, a member of the focal adhesion kinase (FAK) family, in AD pathology and its regulation are largely unknown. To address this, we generated mice with neuronal expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Disks Large Homolog 4 Protein
Share to Focal Adhesion Kinase 2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hippocampus

Share to Microtubule-Associated Proteins

Share to Proto-Oncogene Proteins c-fyn

Share to tau Proteins

Share to Tauopathies

Source

Open in PubMed Open full text

Identifiers

PMID: 29782321
DOI: 10.3233/JAD-180054
PMCID: PMC6004899

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the Tyrosine Kinase Fyn.PMID 29782321Read ↗

Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy.Semantic proximity Read ↗

PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's diseaseSemantic proximity Read ↗

Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology.Semantic proximity Read ↗

Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and LossSemantic proximity Read ↗

Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model.Semantic proximity Read ↗

The Pyk2 FERM regulates Pyk2 complex formation and phosphorylation.Semantic proximity Read ↗

Proline-Rich Protein Tyrosine Kinase 2 in Inflammation and CancerSemantic proximity Read ↗

Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau PathologySemantic proximity Read ↗

Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein.Semantic proximity Read ↗

TTBK2: a tau protein kinase beyond tau phosphorylation.Semantic proximity Read ↗

Biological function of Lemur tyrosine kinase 2 (LMTK2): implications in neurodegenerationSemantic proximity Read ↗

TBK1 interacts with tau and enhances neurodegeneration in tauopathySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.