Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nac1 promotes self-renewal of embryonic stem cells through direct transcriptional regulation of c-Myc.

Oncotarget - 18 Jul 2017

Ruan Yan, He Jianrong, Wu Wei, He Ping, Tian Yanping, Xiao Lan, Liu Gaoke, Wang Jiali, Cheng Yuda, Zhang Shuo, Yang Yi, Xiong Jiaxiang, Zhao Ke, Wan Ying, Huang He, Zhang Junlei, Jian Rui

Abstract excerpt

The pluripotency transcriptional network in embryonic stem cells (ESCs) is composed of distinct functional units including the core and Myc units. It is hoped that dissection of the cellular functions and interconnections of network factors will aid our understanding of ESC and cancer biology. Proteomic and genomic approaches have identified Nac1 as a member of the core pluripotency network. However, previous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Self Renewal
Share to Embryonic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescent Antibody Technique

Share to Gene Knockout Techniques

Share to Genes, myc

Share to Leukemia Inhibitory Factor

Share to Nerve Tissue Proteins

Share to Repressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 28548937
DOI: 10.18632/oncotarget.17744
PMCID: PMC5564591

Genes

LIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nac1 promotes self-renewal of embryonic stem cells through direct transcriptional regulation of c-Myc.PMID 28548937Read ↗

NAC1 Regulates Somatic Cell Reprogramming by Controlling Zeb1 and E-cadherin Expression.Semantic proximity Read ↗

Genomic studies to explore self-renewal and differentiation properties of embryonic stem cells.Semantic proximity Read ↗

A multi-omics integrative analysis based on CRISPR screens re-defines the pluripotency regulatory network in ESCsSemantic proximity Read ↗

Single-Cell Analyses of ESCs Reveal Alternative Pluripotent Cell States and Molecular Mechanisms that Control Self-Renewal.Semantic proximity Read ↗

The Regulation of Self-Renewal in Human Embryonic Stem CellsSemantic proximity Read ↗

Neural stemness unifies cell tumorigenicity and pluripotent differentiation potentialSemantic proximity Read ↗

The transcription factor TFCP2L1 induces expression of distinct target genes and promotes self-renewal of mouse and human embryonic stem cellsSemantic proximity Read ↗

Musashi1 and its short C-terminal variants regulate pluripotency states in embryonic stem cellsSemantic proximity Read ↗

NCOR1 and OCT4 Facilitate Early Reprogramming by Co-Suppressing Fibroblast Gene ExpressionSemantic proximity Read ↗

RNA-Seq analysis reveals pluripotency-associated genes and their interaction networks in human embryonic stem cellsSemantic proximity Read ↗

Genes essential for embryonic stem cells are associated with neurodevelopmental disordersSemantic proximity Read ↗

Nr0b1 is a negative regulator of Zscan4c in mouse embryonic stem cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.