Article

Genes essential for embryonic stem cells are associated with neurodevelopmental disorders

2019-03-04

Abstract excerpt

Mouse embryonic stem cells (mESCs) are a key component in generating mouse models for human diseases and performing basic research on pluripotency, but how many genes are essential for mESCs is still unknown. We performed a genome-wide screen for essential genes in mESCs and compared it to human cells. We found that essential genes are enriched for basic cellular functions, are highly expressed in mESCs, and tend...

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Literature Corpus work: 9613c3d6-c641-5384-a896-27e05a3ab461
DOI: 10.1101/567073

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