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Quantification of multicellular colonization in tumor metastasis using exome-sequencing data.

International journal of cancer - 1 May 2020

Nishino Jo, Watanabe Shuichi, Miya Fuyuki, Kamatani Takashi, Sugawara Toshitaka, Boroevich Keith A, Tsunoda Tatsuhiko

Abstract excerpt

Metastasis is a major cause of cancer-related mortality, and it is essential to understand how metastasis occurs in order to overcome it. One relevant question is the origin of a metastatic tumor cell population. Although the hypothesis of a single-cell origin for metastasis from a primary tumor has long been prevalent, several recent studies using mouse models have supported a multicellular origin of metastasis....

Topics

Biomarkers, Tumor
Cohort Studies
Colorectal Neoplasms
DNA Copy Number Variations
Exome
Gene Expression Regulation, Neoplastic
Humans
Mutation
Neoplasm Metastasis
Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Exome Sequencing

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Identifiers

PMID: 32020592
DOI: 10.1002/ijc.32910
PMCID: PMC7079087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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