Article
Germline INDELs and CNVs in a cohort of colorectal cancer patients: their characteristics, associations with relapse-free survival time, and potential time-varying effects on the risk of relapse.
Cancer medicine - 1 Jun 2017
Werdyani Salem, Yu Yajun, Skardasi Georgia, Xu Jingxiong, Shestopaloff Konstantin, Xu Wei, Dicks Elizabeth, Green Jane, Parfrey Patrick, Yilmaz Yildiz E, Savas Sevtap
Abstract excerpt
INDELs and CNVs are structural variations that may play roles in cancer susceptibility and patient outcomes. Our objectives were a) to computationally detect and examine the genome-wide INDEL/CNV profiles in a cohort of colorectal cancer patients, and b) to examine the associations of frequent INDELs/CNVs with relapse-free survival time. We also identified unique variants in 13 Familial Colorectal Cancer Type X...
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