Article
A comprehensive analysis of SNPs and CNVs identifies novel markers associated with disease outcomes in colorectal cancer.
Molecular oncology - 1 Dec 2021
Yu Yajun, Werdyani Salem, Carey Megan, Parfrey Patrick, Yilmaz Yildiz E, Savas Sevtap
Abstract excerpt
We aimed to examine the associations of a genome-wide set of single nucleotide polymorphisms (SNPs) and 254 copy number variations (CNVs) and/or insertion/deletions (INDELs) with clinical outcomes in colorectal cancer patients (n = 505). We also aimed to investigate whether their associations changed (e.g., appeared, diminished) over time. Multivariable Cox proportional hazards and piece-wise Cox regression...
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