Article
Validating regulatory predictions from diverse bacteria with mutant fitness data.
PloS one - 1 Jan 2017
Sagawa Shiori, Price Morgan N, Deutschbauer Adam M, Arkin Adam P
Abstract excerpt
Although transcriptional regulation is fundamental to understanding bacterial physiology, the targets of most bacterial transcription factors are not known. Comparative genomics has been used to identify likely targets of some of these transcription factors, but these predictions typically lack experimental support. Here, we used mutant fitness data, which measures the importance of each gene for a bacterium's...
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