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Article

Persistence and plasticity in bacterial gene regulation.

Nature methods - 1 Dec 2021

Baumgart Leo A, Lee Ji Eun, Salamov Asaf, Dilworth David J, Na Hyunsoo, Mingay Matthew, Blow Matthew J, Zhang Yu, Yoshinaga Yuko, Daum Chris G, O'Malley Ronan C

Abstract excerpt

Organisms orchestrate cellular functions through transcription factor (TF) interactions with their target genes, although these regulatory relationships are largely unknown in most species. Here we report a high-throughput approach for characterizing TF-target gene interactions across species and its application to 354 TFs across 48 bacteria, generating 17,000 genome-wide binding maps. This dataset revealed...

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PMID: 34824476
DOI: 10.1038/s41592-021-01312-2

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