Article
Mutant phenotypes for thousands of bacterial genes of unknown function.
Nature - 1 May 2018
Price Morgan N, Wetmore Kelly M, Waters R Jordan, Callaghan Mark, Ray Jayashree, Liu Hualan, Kuehl Jennifer V, Melnyk Ryan A, Lamson Jacob S, Suh Yumi, Carlson Hans K, Esquivel Zuelma, Sadeeshkumar Harini, Chakraborty Romy, Zane Grant M, Rubin Benjamin E, Wall Judy D, Visel Axel, Bristow James, Blow Matthew J, Arkin Adam P, Deutschbauer Adam M
Abstract excerpt
One-third of all protein-coding genes from bacterial genomes cannot be annotated with a function. Here, to investigate the functions of these genes, we present genome-wide mutant fitness data from 32 diverse bacteria across dozens of growth conditions. We identified mutant phenotypes for 11,779 protein-coding genes that had not been annotated with a specific function. Many genes could be associated with a...
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