Article
Association of CYP2A6 activity with lung cancer incidence in smokers: The multiethnic cohort study.
PloS one - 1 Jan 2017
Park Sungshim L, Murphy Sharon E, Wilkens Lynne R, Stram Daniel O, Hecht Stephen S, Le Marchand Loïc
Abstract excerpt
While smoking is the primary cause of lung cancer, only 11-24% of smokers develop the malignancy over their lifetime. The primary addictive agent in tobacco smoke is nicotine and variation in nicotine metabolism may influence the smoking levels of an individual. Therefore, inter-individual variation in lung cancer risk among smokers may be due in part to differences in the activity of enzymes involved in nicotine...
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