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Article

CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study.

Carcinogenesis - 1 Apr 2017

Yuan Jian-Min, Nelson Heather H, Carmella Steven G, Wang Renwei, Kuriger-Laber Jacquelyn, Jin Aizhen, Adams-Haduch Jennifer, Hecht Stephen S, Koh Woon-Puay, Murphy Sharon E

Abstract excerpt

Cytochrome P450 2A6 (CYP2A6) catalyzes the metabolism of nicotine and the tobacco-specific lung carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Genetic variation in CYP2A6 may affect smoking behavior and contribute to lung cancer risk. A nested case-control study of 197 lung cancer cases and 197 matched controls was conducted within a prospective cohort of 63 257 Chinese men and women in...

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Identifiers

PMID: 28182203
DOI: 10.1093/carcin/bgx012
PMCID: PMC6248819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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