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Article

Deletion of Pdcd5 in mice led to the deficiency of placenta development and embryonic lethality

25 May 2017

Abstract excerpt

Abstract Programmed cell death 5 (PDCD5) is an apoptosis promoter molecule that displays multiple biological activities. However, the function of PDCD5 in vivo has not yet been investigated. Here, we generated a Pdcd5 knockout mouse model to study the physiological role of PDCD5 in vivo. Knockout of the Pdcd5 gene resulted in embryonic lethality at mid-gestation. Histopathological analysis revealed dysplasia in...

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PMID: 28542142
DOI: 10.1038/cddis.2017.124

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