Article
Generation and identification of a conditional knockout allele for the PSMD11 gene in mice.
BMC developmental biology - 1 Feb 2021
Zhao Linlin, Zhao Jinming, Zhang Yingying, Wang Lele, Zuo Longyan, Niu Airu, Zhang Wei, Xue Xia, Zhao Suhong, Sun Chao, Li Kailin, Wang Jue, Bian Zhimin, Zhao Xiaogang, Saur Dieter, Seidler Barbara, Wang Chuanxin, Qi Tonggang
Abstract excerpt
BACKGROUND: Our previous study have shown that the PSMD11 protein was an important survival factor for cancer cells except for its key role in regulation of assembly and activity of the 26S proteasome. To further investigate the role of PSMD11 in carcinogenesis, we constructed a conditional exon 5 floxed allele of PSMD11 (PSMD11flx) in mice. RESULTS: It was found that homozygous PSMD11 flx/flx mice showed normal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.