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Gene-based sequencing identifies lipid-influencing variants with ethnicity-specific effects in African Americans.

PLoS genetics - 1 Mar 2014

Bentley Amy R, Chen Guanjie, Shriner Daniel, Doumatey Ayo P, Zhou Jie, Huang Hanxia, Mullikin James C, Blakesley Robert W, Hansen Nancy F, Bouffard Gerard G, Cherukuri Praveen F, Maskeri Baishali, Young Alice C, Adeyemo Adebowale, Rotimi Charles N

Abstract excerpt

Although a considerable proportion of serum lipids loci identified in European ancestry individuals (EA) replicate in African Americans (AA), interethnic differences in the distribution of serum lipids suggest that some genetic determinants differ by ethnicity. We conducted a comprehensive evaluation of five lipid candidate genes to identify variants with ethnicity-specific effects. We sequenced ABCA1, LCAT, LPL,...

Topics

Black or African American
Ethnicity
Genetic Variation
Genome-Wide Association Study
Genotype
High-Throughput Nucleotide Sequencing
Humans
Linkage Disequilibrium
Lipids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

White People

Source

Open in PubMed Open full text

Identifiers

PMID: 24603370
DOI: 10.1371/journal.pgen.1004190
PMCID: PMC3945436

Genes

LPL
ABCA1
LCAT
PON1
SERPINE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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