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Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry.

Nature communications - 5 Sept 2023

Kamiza Abram Bunya, Touré Sounkou M, Zhou Feng, Soremekun Opeyemi, Cissé Cheickna, Wélé Mamadou, Touré Aboubacrine M, Nashiru Oyekanmi, Corpas Manuel, Nyirenda Moffat, Crampin Amelia, Shaffer Jeffrey, Doumbia Seydou, Zeggini Eleftheria, Morris Andrew P, Asimit Jennifer L, Chikowore Tinashe, Fatumo Segun

Abstract excerpt

Most genome-wide association studies (GWAS) for lipid traits focus on the separate analysis of lipid traits. Moreover, there are limited GWASs evaluating the genetic variants associated with multiple lipid traits in African ancestry. To further identify and localize loci with pleiotropic effects on lipid traits, we conducted a genome-wide meta-analysis, multi-trait analysis of GWAS (MTAG), and multi-trait...

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Black People
Genome-Wide Association Study
Lipids
Phenotype

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PMID: 37669986
DOI: 10.1038/s41467-023-41271-0
PMCID: PMC10480211

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