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Article

Interaction of glycosphingolipids GD3 and GD2 with growth factor receptors maintains breast cancer stem cell phenotype.

Oncotarget - 18 Jul 2017

Liang Yuh-Jin, Wang Chen-Yu, Wang I-An, Chen Yi-Wen, Li Li-Tzu, Lin Chuang-Yu, Ho Ming-Yi, Chou Tsung-Lung, Wang Ya-Hui, Chiou Shih-Pin, Lin Yu-Ju, Yu John

Abstract excerpt

Many studies have suggested that disialogangliosides, GD2 and GD3, are involved in the development of various tumor types. However, the functional relationships between ganglioside expression and cancer development or aggressiveness are not fully described. GD3 is upregulated in approximately half of all invasive ductal breast carcinoma cases, and enhanced expression of GD3 synthase (GD3S,...

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Identifiers

PMID: 28537895
DOI: 10.18632/oncotarget.17665
PMCID: PMC5564578

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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