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Article

Repression of the stress granule protein G3BP2 inhibits immune checkpoint molecule PD‐L1

3 Feb 2021

Abstract excerpt

Mounting evidence suggests that cancer stemness and immunosuppression are related, but the underlying mechanisms behind these are not clear. We previously reported that the stress granule-associated protein G3BP2 is involved in the regulation of tumor-initiating (stem) cells. In this study, we show that this protein also upregulates the immune checkpoint molecule PD-L1 under conditions of stress in breast and...

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PMID: 33525064
DOI: 10.1002/1878-0261.12915

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