Article
The ganglioside G(D2) induces the constitutive activation of c-Met in MDA-MB-231 breast cancer cells expressing the G(D3) synthase.
Glycobiology - 1 Jun 2012
Cazet Aurélie, Bobowski Marie, Rombouts Yoann, Lefebvre Jonathan, Steenackers Agata, Popa Iuliana, Guérardel Yann, Le Bourhis Xuefen, Tulasne David, Delannoy Philippe
Abstract excerpt
We have recently established and characterized cellular clones deriving from MDA-MB-231 breast cancer cells that express the human G(D3) synthase (GD3S), the enzyme that controls the biosynthesis of b- and c-series gangliosides. The GD3S positive clones show a proliferative phenotype in the absence of serum or growth factors and an increased tumor growth in severe immunodeficient mice. This phenotype results from...
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