Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters

15 Nov 2023

Abstract excerpt

The heterogeneity of cancer stem cells (CSCs) within tumors presents a challenge in therapeutic targeting. To decipher the cellular plasticity that fuels phenotypic heterogeneity, we undertook single-cell transcriptomics analysis in triple-negative breast cancer (TNBC) to identify subpopulations in CSCs. We found a subpopulation of CSCs with ancestral features that is marked by FXYD domain-containing ion...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Genomics and Diagnostics
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37966117
DOI: 10.1172/jci166666

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persistersPMID 37966117Read ↗

Cancer Stem Cell Transcriptome Landscape Reveals Biomarkers Driving Breast Cancer HeterogeneitySemantic proximity Read ↗

An update on cancer stem cell survival pathways involved in chemoresistance in triple-negative breast cancerSemantic proximity Read ↗

Therapeutic vulnerabilities in triple negative breast cancer: Stem-like traits explored within molecular classification.Semantic proximity Read ↗

Stemness of Cancer: A Study of Triple-negative Breast Cancer From a Neuroscience PerspectiveSemantic proximity Read ↗

A single cell atlas of the healthy breast tissues reveal clinically relevant clusters of breast epithelial cellsSemantic proximity Read ↗

Identification of Distinct Breast Cancer Stem Cell Populations Based on Single-Cell Analyses of Functionally Enriched Stem and Progenitor Pools.Semantic proximity Read ↗

Breast cancer stem cells mediated CD8 <sup>+</sup> T cell exhaustion among different molecular subtypes of breast cancer regulated via NOTCH1/RBPJ/PD-L1 axisSemantic proximity Read ↗

Targeting EMSY-mediated methionine metabolism is a potential therapeutic strategy for triple-negative breast cancerSemantic proximity Read ↗

Transcriptional landscape associated with TNBC resistance to neoadjuvant chemotherapy revealed by single-cell RNA-seqSemantic proximity Read ↗

ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell ProgramSemantic proximity Read ↗

Cell State Transitions and Phenotypic Heterogeneity in Luminal Breast Cancer Implicating MicroRNAs as Potential Regulators.Semantic proximity Read ↗

Transcriptomic but not genomic variability confers phenotype of breast cancer stem cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.