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Elevated transcription and glycosylation of B3GNT5 promotes breast cancer aggressiveness

7 May 2022

Abstract excerpt

BACKGROUND: Basal-like breast cancer (BLBC) is the most aggressive subtype of breast cancer because of its aggressive biological characteristics and no effective targeted agents. However, the mechanism underlying its aggressive behavior remain poorly understood. β1,3-N-acetylglucosaminyltransferase V (B3GNT5) overexpression occurs specifically in BLBC. Here, we studied the possible molecular mechanisms of B3GBT5...

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PMID: 35526049
DOI: 10.1186/s13046-022-02375-5

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