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The biological role and immunotherapy of gangliosides and GD3 synthase in cancers

7 Feb 2023

Abstract excerpt

Gangliosides are a large subfamily of glycosphingolipids that broadly exist in the nervous system and interact with signaling molecules in the lipid rafts. GD3 and GD2 are two types of disialogangliosides (GDs) that include two sialic acid residues. The expression of GD3 and GD2 in various cancers is mostly upregulated and is involved in tumor proliferation, invasion, metastasis, and immune responses. GD3...

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Identifiers

PMID: 36824365
DOI: 10.3389/fcell.2023.1076862

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