Ganglioside GD2 Contributes to a Stem-Like Phenotype in Intrahepatic Cholangiocarcinoma.

doi:10.1111/liv.16208

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Article

Ganglioside GD2 Contributes to a Stem-Like Phenotype in Intrahepatic Cholangiocarcinoma.

Liver international : official journal of the International Association for the Study of the Liver - 1 Jan 2025

Mannini Antonella, Pastore Mirella, Giachi Alessia, Correnti Margherita, Spínola Lasso Elena, Lottini Tiziano, Piombanti Benedetta, Tusa Ignazia, Rovida Elisabetta, Coulouarn Cédric, Andersen Jesper B, Lewinska Monika, Campani Claudia, Battula V Lokesh, Yuan Bin, Aureli Massimo, Carsana Emma V, Peraldo Neia Caterina, Ostano Paola, Tani Alessia, Nosi Daniele, Vanni Anna, Maggi Laura, Di Tommaso Luca, Comito Giuseppina, Madiai Stefania, Arcangeli Annarosa, Marra Fabio, Raggi Chiara

Abstract excerpt

BACKGROUND & AIMS: GD2, a member of the ganglioside (GS) family (sialic acid-containing glycosphingolipids), is a potential biomarker of cancer stem cells (CSC) in several tumours. However, the possible role of GD2 and its biosynthetic enzyme, GD3 synthase (GD3S), in intrahepatic cholangiocarcinoma (iCCA) has not been explored. METHODS: The stem-like subset of two iCCA cell lines was enriched by sphere culture...

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PMID: 39726234
DOI: 10.1111/liv.16208
PMCID: PMC11684508

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