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Article

A single mutation in the envelope protein modulates flavivirus antigenicity, stability, and pathogenesis.

PLoS pathogens - 1 Feb 2017

Goo Leslie, VanBlargan Laura A, Dowd Kimberly A, Diamond Michael S, Pierson Theodore C

Abstract excerpt

The structural flexibility or 'breathing' of the envelope (E) protein of flaviviruses allows virions to sample an ensemble of conformations at equilibrium. The molecular basis and functional consequences of virus conformational dynamics are poorly understood. Here, we identified a single mutation at residue 198 (T198F) of the West Nile virus (WNV) E protein domain I-II hinge that regulates virus breathing. The...

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Source

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Identifiers

PMID: 28207910
DOI: 10.1371/journal.ppat.1006178
PMCID: PMC5312798

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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