Article
Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium.
Scientific reports - 22 May 2017
Skaaby Tea, Taylor Amy E, Jacobsen Rikke K, Paternoster Lavinia, Thuesen Betina H, Ahluwalia Tarunveer S, Larsen Sofus C, Zhou Ang, Wong Andrew, Gabrielsen Maiken E, Bjørngaard Johan H, Flexeder Claudia, Männistö Satu, Hardy Rebecca, Kuh Diana, Barry Sarah J, Tang Møllehave Line, Cerqueira Charlotte, Friedrich Nele, Bonten Tobias N, Noordam Raymond, Mook-Kanamori Dennis O, Taube Christian, Jessen Leon E, McConnachie Alex, Sattar Naveed, Upton Mark N, McSharry Charles, Bønnelykke Klaus, Bisgaard Hans, Schulz Holger, Strauch Konstantin, Meitinger Thomas, Peters Annette, Grallert Harald, Nohr Ellen A, Kivimaki Mika, Kumari Meena, Völker Uwe, Nauck Matthias, Völzke Henry, Power Chris, Hyppönen Elina, Hansen Torben, Jørgensen Torben, Pedersen Oluf, Salomaa Veikko, Grarup Niels, Langhammer Arnulf, Romundstad Pål R, Skorpen Frank, Kaprio Jaakko, R Munafò Marcus, Linneberg Allan
Abstract excerpt
Observational studies on smoking and risk of hay fever and asthma have shown inconsistent results. However, observational studies may be biased by confounding and reverse causation. Mendelian randomization uses genetic variants as markers of exposures to examine causal effects. We examined the causal effect of smoking on hay fever and asthma by using the smoking-associated single nucleotide polymorphism (SNP)...
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