Article
Estimating the causal effect of body mass index on hay fever, asthma and lung function using Mendelian randomization.
Allergy - 1 Jan 2018
Skaaby T, Taylor A E, Thuesen B H, Jacobsen R K, Friedrich N, Møllehave L T, Hansen S, Larsen S C, Völker U, Nauck M, Völzke H, Hansen T, Pedersen O, Jørgensen T, Paternoster L, Munafò M, Grarup N, Linneberg A
Abstract excerpt
BACKGROUND: Observational studies have shown that body mass index (BMI) is positively associated with asthma. However, observational data are prone to confounding and reverse causation. In Mendelian randomization, genetic variants are used as unconfounded markers of exposures to examine causal effects. We examined the causal effect of BMI on asthma, hay fever, allergic sensitization, serum total immunoglobulin E...
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