Article
Associations of genetic determinants of serum vitamin B12 and folate concentrations with hay fever and asthma: a Mendelian randomization meta-analysis.
European journal of clinical nutrition - 1 Feb 2018
Skaaby Tea, Taylor Amy E, Jacobsen Rikke K, Møllehave Line T, Friedrich Nele, Thuesen Betina H, Shabanzadeh Daniel Mønsted, Paternoster Lavinia, Völker Uwe, Nauck Matthias, Völzke Henry, Munafò Marcus, Hansen Torben, Pedersen Oluf, Jørgensen Torben, Grarup Niels, Linneberg Allan
Abstract excerpt
BACKGROUND/OBJECTIVES: Studies of the effect of vitamin B12 and folate on the risk of asthma and hay fever have shown inconsistent results that may be biased by reverse causation and confounding. We used a Mendelian randomization approach to examine a potential causal effect of vitamin B12 and folate on hay fever, asthma, and selected biomarkers of allergy by using 11 vitamin B12-associated single-nucleotide...
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