Improving the power to detect risk variants for allergic disease by defining case-control status based on both asthma and hay fever.

Abstract excerpt

Asthma and hay fever are likely to share hundreds if not thousands of genetic risk variants. Despite this, the extent to which the power to identify shared risk variants could be improved by considering information from both diseases when designing or analyzing genetic studies has not been studied in detail. Simulations were performed to quantify the power to detect an association between case-control status and...

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