Article
IGF1 stimulates greater muscle hypertrophy in the absence of myostatin in male mice.
The Journal of endocrinology - 1 Aug 2017
Hennebry Alexander, Oldham Jenny, Shavlakadze Tea, Grounds Miranda D, Sheard Philip, Fiorotto Marta L, Falconer Shelley, Smith Heather K, Berry Carole, Jeanplong Ferenc, Bracegirdle Jeremy, Matthews Kenneth, Nicholas Gina, Senna-Salerno Mônica, Watson Trevor, McMahon Christopher D
Abstract excerpt
Insulin-like growth factors (IGFs) and myostatin have opposing roles in regulating the growth and size of skeletal muscle, with IGF1 stimulating, and myostatin inhibiting, growth. However, it remains unclear whether these proteins have mutually dependent, or independent, roles. To clarify this issue, we crossed myostatin null (Mstn-/-) mice with mice overexpressing Igf1 in skeletal muscle (Igf1+) to generate six...
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