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Myostatin is a key mediator between energy metabolism and endurance capacity of skeletal muscle.

American journal of physiology. Regulatory, integrative and comparative physiology - 15 Aug 2014

Mouisel Etienne, Relizani Karima, Mille-Hamard Laurence, Denis Raphaël, Hourdé Christophe, Agbulut Onnik, Patel Ketan, Arandel Ludovic, Morales-Gonzalez Susanne, Vignaud Alban, Garcia Luis, Ferry Arnaud, Luquet Serge, Billat Véronique, Ventura-Clapier Renée, Schuelke Markus, Amthor Helge

Abstract excerpt

Myostatin (Mstn) participates in the regulation of skeletal muscle size and has emerged as a regulator of muscle metabolism. Here, we hypothesized that lack of myostatin profoundly depresses oxidative phosphorylation-dependent muscle function. Toward this end, we explored Mstn(-/-) mice as a model for the constitutive absence of myostatin and AAV-mediated overexpression of myostatin propeptide as a model of...

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Lactic Acid
Mitochondria, Muscle
Muscle Contraction
Myostatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

Phosphopyruvate Hydratase

Physical Endurance

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PMID: 24965795
DOI: 10.1152/ajpregu.00377.2013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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