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Article

Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control.

Nature cell biology - 1 Mar 2005

Ohanna Mickaël, Sobering Andrew K, Lapointe Thomas, Lorenzo Lazaro, Praud Christophe, Petroulakis Emmanuel, Sonenberg Nahum, Kelly Paul A, Sotiropoulos Athanassia, Pende Mario

Abstract excerpt

The mammalian target of rapamycin (mTOR) and Akt proteins regulate various steps of muscle development and growth, but the physiological relevance and the downstream effectors are under investigation. Here we show that S6 kinase 1 (S6K1), a protein kinase activated by nutrients and insulin-like growth factors (IGFs), is essential for the control of muscle cytoplasmic volume by Akt and mTOR. Deletion of S6K1 does...

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Identifiers

PMID: 15723049
DOI: 10.1038/ncb1231

Genes

IGF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control.PMID 15723049Read ↗

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