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Article

Paracrine and endocrine modes of myostatin action.

Journal of applied physiology (Bethesda, Md. : 1985) - 15 Mar 2016

Lee Yun-Sil, Huynh Thanh V, Lee Se-Jin

Abstract excerpt

Myostatin (MSTN) is a secreted signaling molecule that normally acts to limit muscle mass. In adult animals, MSTN is made almost exclusively by skeletal muscle and circulates in the blood. A critical question is whether this circulating MSTN protein can enter the active pool to regulate muscle growth or whether all of the activity of MSTN results from locally produced protein. Here, we addressed this question in...

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Identifiers

PMID: 26769954
DOI: 10.1152/japplphysiol.00874.2015
PMCID: PMC4796182

Genes

MSTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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