Elevated insulin-like growth factor 2 expression may contribute to the hypermuscular phenotype of myostatin null mice.

doi:10.1016/j.ghir.2015.06.007

Article

Elevated insulin-like growth factor 2 expression may contribute to the hypermuscular phenotype of myostatin null mice.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society - 1 Oct 2015

Clark Daniel L, Clark Diana I, Hogan Elizabeth K, Kroscher Kellie A, Dilger Anna C

Abstract excerpt

OBJECTIVES: Myostatin (Mstn) inhibits while insulin-like growth factors 1 and 2 (Igf1 and Igf2) increase skeletal muscle growth. However, there is little known regarding Mstn regulation of Igf1 and Igf2 expression. Therefore, the objective of this study was to quantify the expression of IGF family members in skeletal muscle and liver throughout the growth phase of Mstn null (MN) mice. Further, differences between...

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Elevated insulin-like growth factor 2 expression may contribute to the hypermuscular phenotype of myostatin null mice.

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