Article
Reading LINEs within the cocaine addicted brain.
Brain and behavior - 1 May 2017
Doyle Glenn A, Doucet-O'Hare Tara T, Hammond Matthew J, Crist Richard C, Ewing Adam D, Ferraro Thomas N, Mash Deborah C, Kazazian Haig H, Berrettini Wade H
Abstract excerpt
INTRODUCTION: Long interspersed element (LINE)-1 (L1) is a type of retrotransposon capable of mobilizing into new genomic locations. Often studied in Mendelian diseases or cancer, L1s may also cause somatic mutation in the developing central nervous system. Recent reports showed L1 transcription was activated in brains of cocaine-treated mice, and L1 retrotransposition was increased in cocaine-treated neuronal...
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