Article
Increased l1 retrotransposition in the neuronal genome in schizophrenia.
Neuron - 22 Jan 2014
Bundo Miki, Toyoshima Manabu, Okada Yohei, Akamatsu Wado, Ueda Junko, Nemoto-Miyauchi Taeko, Sunaga Fumiko, Toritsuka Michihiro, Ikawa Daisuke, Kakita Akiyoshi, Kato Motoichiro, Kasai Kiyoto, Kishimoto Toshifumi, Nawa Hiroyuki, Okano Hideyuki, Yoshikawa Takeo, Kato Tadafumi, Iwamoto Kazuya
Abstract excerpt
Recent studies indicate that long interspersed nuclear element-1 (L1) are mobilized in the genome of human neural progenitor cells and enhanced in Rett syndrome and ataxia telangiectasia. However, whether aberrant L1 retrotransposition occurs in mental disorders is unknown. Here, we report high L1 copy number in schizophrenia. Increased L1 was demonstrated in neurons from prefrontal cortex of patients and in...
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