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Article

A unique H2A histone variant occupies the transcriptional start site of active genes.

Nature structural & molecular biology - 4 Dec 2011

Soboleva Tatiana A, Nekrasov Maxim, Pahwa Anuj, Williams Rohan, Huttley Gavin A, Tremethick David J

Abstract excerpt

Transcriptional activation is controlled by chromatin, which needs to be unfolded and remodeled to ensure access to the transcription start site (TSS). However, the mechanisms that yield such an 'open' chromatin structure, and how these processes are coordinately regulated during differentiation, are poorly understood. We identify the mouse (Mus musculus) H2A histone variant H2A.Lap1 as a previously undescribed...

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PMID: 22139013
DOI: 10.1038/nsmb.2161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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