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Article

Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice.

Molecular and cellular biology - 1 Aug 2017

Suzuki Takuma, Murakami Shohei, Biswal Shyam S, Sakaguchi Shimon, Harigae Hideo, Yamamoto Masayuki, Motohashi Hozumi

Abstract excerpt

The transcription factor NRF2 (nuclear factor [erythroid-derived 2]-like 2) plays crucial roles in the defense mechanisms against oxidative stress and mediates anti-inflammatory actions under various pathological conditions. Recent studies showed that the dysfunction of regulatory T cells (Tregs) is directly linked to the initiation and progression of various autoimmune diseases. To determine the Treg-independent...

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Identifiers

PMID: 28507037
DOI: 10.1128/MCB.00063-17
PMCID: PMC5514445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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