Article
Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1991
Godfrey V L, Wilkinson J E, Rinchik E M, Russell L B
Abstract excerpt
Characteristic lesions in mice hemi- or homozygous for the X-linked mutation scurfy (sf) include lymphohistiocytic proliferation in the skin and lymphoid organs, Coombs' test-positive anemia, hypergammaglobulinemia, and death by 24 days of age. The role of the thymus in the development of fatal lymphoreticular disease in the scurfy mouse was investigated. Neonatal thymectomy doubles the life span of scurfy mice,...
Topics
- Animals
- Animals, Newborn
- Bone Marrow Transplantation
- Genes, Lethal
- Genes, Recessive
- Lymphoproliferative Disorders
- Mice
- Mice, Mutant Strains
- Mice, Nude
- Phenotype