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Article

X-linked Foxp3 (Scurfy) mutation dominantly inhibits submandibular gland development and inflammation respectively through adaptive and innate immune mechanisms.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2009

Sharma Rahul, Deshmukh Umesh S, Zheng Lingjie, Fu Shu Man, Ju Shyr-Te

Abstract excerpt

Scurfy (Foxp3(Sf)/Y), Il2(-/-), and Il2ralpha(-/-) mice are deficient in CD4(+)Foxp3(+) regulatory T cells (Treg), but only the latter two develop inflammation in the submandibular gland (SMG), a critical target of Sjögren's syndrome. In this study, we investigated the reason that SMG of Scurfy (Sf), Sf.Il2(-/-), Sf.Il2ralpha(-/-), and the long-lived Sf.Fas(lpr/lpr) mice remained free of inflammation, even though...

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Identifiers

PMID: 19648271
DOI: 10.4049/jimmunol.0804355
PMCID: PMC2735024

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Source receipt: pubmed, retrieved 7 Sept 2026.

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