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Article

Nrf2 exerts cell-autonomous antifibrotic effects: compromised function in systemic sclerosis and therapeutic rescue with a novel heterocyclic chalcone derivative.

Translational research : the journal of laboratory and clinical medicine - 1 May 2017

Wei Jun, Zhu Hongyan, Lord Gabriel, Bhattachayya Mitra, Jones Brielle M, Allaway Graham, Biswal Shyam S, Korman Benjamin, Marangoni Roberta G, Tourtellotte Warren G, Varga John

Abstract excerpt

The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) governs antioxidant, innate immune and cytoprotective responses and its deregulation is prominent in chronic inflammatory conditions. To examine the hypothesis that Nrf2 might be implicated in systemic sclerosis (SSc), we investigated its expression, activity, and mechanism of action in SSc patient samples and mouse models of fibrosis and...

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Identifiers

PMID: 28027929
DOI: 10.1016/j.trsl.2016.12.002
PMCID: PMC7205471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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