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Article

Targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jun 2004

Lee Jong-Min, Chan Kaimin, Kan Yuet Wai, Johnson Jeffrey A

Abstract excerpt

A basic leucine zipper transcription factor, NF-E2-related factor 2 (Nrf2), plays a critical role in the cellular defense mechanism by mediating a coordinate up-regulation of antioxidant responsive element-driven detoxification and antioxidant genes. Here, we report that targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia due to increased sequestration of damaged erythrocytes....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15210949
DOI: 10.1073/pnas.0403620101
PMCID: PMC470746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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