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Article

Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice.

Physiological genomics - 11 Aug 2004

Li Jiang, Stein Thor D, Johnson Jeffrey A

Abstract excerpt

Systemic lupus erythematosus (SLE) is an autoimmune disorder with immune-complex deposition that affects multiple organs. Previous studies have suggested the involvement of oxidative stress and apoptosis in SLE, but no clear link to etiology has been established. Here we show that mice deficient in a transcription factor responsible for controlling the expression of numerous detoxification and antioxidant genes...

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Source

Identifiers

PMID: 15173550
DOI: 10.1152/physiolgenomics.00209.2003

Genes

C3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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