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Article

Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype.

Blood - 27 Sept 2012

Mantel Charlie, Messina-Graham Steven, Moh Akira, Cooper Scott, Hangoc Giao, Fu Xin-Yuan, Broxmeyer Hal E

Abstract excerpt

Nuclear transcription factor Stat3 is important for proper regulation of hematopoietic stem cell (HSC) and hematopoietic progenitor cell (HPC) proliferation, survival, and cytokine signaling responses. A new, noncanonical role for Stat3 in mitochondrial function has been discovered recently. However, there is little information on the role(s) of mitochondrial Stat3 in HSC/HPC function, especially potential...

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Identifiers

PMID: 22665934
DOI: 10.1182/blood-2012-01-404004
PMCID: PMC3460681

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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