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Article

Sensitivity of hematopoietic stem cells to mitochondrial dysfunction by SdhD gene deletion

8 Dec 2016

Abstract excerpt

It is established that hematopoietic stem cells (HSC) in the hypoxic bone marrow have adapted their metabolism to oxygen-limiting conditions. This adaptation includes suppression of mitochondrial activity, induction of anerobic glycolysis, and activation of hypoxia-inducible transcription factor 1α (Hif1α)-dependent gene expression. During progression of hematopoiesis, a metabolic switch towards mitochondrial...

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PMID: 27929539
DOI: 10.1038/cddis.2016.411

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