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Article

Exploring resistance pathways for first-generation NS3/4A protease inhibitors boceprevir and telaprevir using Bayesian network learning.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Sept 2017

Cuypers Lize, Libin Pieter, Schrooten Yoeri, Theys Kristof, Di Maio Velia Chiara, Cento Valeria, Lunar Maja M, Nevens Frederik, Poljak Mario, Ceccherini-Silberstein Francesca, Nowé Ann, Van Laethem Kristel, Vandamme Anne-Mieke

Abstract excerpt

Resistance-associated variants (RAVs) have been shown to influence treatment response to direct-acting antivirals (DAAs) and first generation NS3/4A protease inhibitors (PIs) in particular. Interpretation of hepatitis C virus (HCV) genotypic drug resistance remains a challenge, especially in patients who previously failed DAA therapy and need to be retreated with a second DAA based regimen. Bayesian network (BN)...

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Identifiers

PMID: 28499845
DOI: 10.1016/j.meegid.2017.05.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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