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Article

Coordinated evolution among hepatitis C virus genomic sites is coupled to host factors and resistance to interferon

1 Jan 2012

Abstract excerpt

Machine-learning methods in the form of Bayesian networks (BN), linear projection (LP) and self-organizing tree (SOT) models were used to explore association among polymorphic sites within the HVR1 and NS5a regions of the HCV genome, host demographic factors (ethnicity, gender and age) and response to the combined interferon (IFN) and ribavirin (RBV) therapy. The BN models predicted therapy outcomes, gender and...

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PMID: 23202423
DOI: 10.3233/isb-2012-0456

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