Article
Analysis of HIV-1 pol sequences using Bayesian Networks: implications for drug resistance.
Bioinformatics (Oxford, England) - 15 Dec 2006
Deforche K, Silander T, Camacho R, Grossman Z, Soares M A, Van Laethem K, Kantor R, Moreau Y, Vandamme A-M
Abstract excerpt
Human Immunodeficiency Virus-1 (HIV-1) antiviral resistance is a major cause of antiviral therapy failure and compromises future treatment options. As a consequence, resistance testing is the standard of care. Because of the high degree of HIV-1 natural variation and complex interactions, the role of resistance mutations is in many cases insufficiently understood. We applied a probabilistic model, Bayesian...
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