Article
Bayesian network analyses of resistance pathways against efavirenz and nevirapine.
AIDS (London, England) - 18 Oct 2008
Deforche Koen, Camacho Ricardo J, Grossman Zehave, Soares Marcelo A, Van Laethem Kristel, Katzenstein David A, Harrigan P Richard, Kantor Rami, Shafer Robert, Vandamme Anne-Mieke
Abstract excerpt
OBJECTIVE: To clarify the role of novel mutations selected by treatment with efavirenz or nevirapine, and investigate the influence of HIV-1 subtype on nonnucleoside reverse transcriptase inhibitor (nNRTI) resistance pathways. DESIGN: By finding direct dependencies between treatment-selected mutations, the involvement of these mutations as minor or major resistance mutations against efavirenz, nevirapine, or...
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