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Article

Externally Validated Probabilistic Modeling of a Predefined Entecavir Resistance Pathway in HBV Using Independent Public Repositories.

Viruses - 27 May 2026

Kapatais Christelos, Karaoulani Fanie, Fortis Sotirios P, Saritzoglou Matina, Martsoukos Nikolaos, Kapatais Andreas

Abstract excerpt

BACKGROUND: Accurate interpretation of hepatitis B virus (HBV) polymerase sequences is essential for identifying antiviral resistance, particularly for high-genetic-barrier agents such as entecavir. Current resistance interpretation relies largely on deterministic rule-based systems that do not quantify uncertainty and are difficult to evaluate across independent datasets. We aimed to develop and externally...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42357620
DOI: 10.3390/v18060610
PMCID: PMC13308312

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